Figure 1: Schematic to demonstrate the position and orientation of binding of a ZFNs pair to a specific DNA sequence to enable generation of a double strand break in the DNA.
Figure 2: Schematic to demonstrate potential outcomes of a double-strand break in DNA generated by a pair of ZFNs, gene disruption, gene correction or DNA insertion.
Original Source: http://www.sangamo.com/technology/zf-nucleases.html
