Cells Rejuvenation Strategy

(Continuously Updating)

Paper 1: Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration.

Strategy : 

1.  cytokine enhancement of a biodegradable patch
1.  covalently immobilized 2 proangiogenic cytokines (vascular endothelial growth factor and basic fibroblast growth factor) onto porous collagen scaffolds.
2.  seeded human mesenchymal stromal cells from old donors into the scaffolds with  growth factors. 

Application: 

1. Surgical ventricular restoration (SVR)

References:

1. Kang K, Sun L, Xiao Y, Li SH, Wu J, Guo J, Jiang SL, Yang L, Yau TM, Weisel RD, Radisic M, Li RK. Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. J Am Coll Cardiol. 2012 Nov 20;60(21):2237-49. doi: 10.1016/j.jacc.2012.08.985. (Department of Cardiovascular Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China; Division of Cardiovascular Surgery and Toronto General Research Institute, University Health Network and Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada.) PMID: 23153846