Protein Injection Strategy

(Continuously Updating)

Paper 1: Wnt7a treatment ameliorates muscular dystrophy

Strategy :

1.  Wnt7a treatment efficiently induced satellite cell expansion and myofiber hypertrophy in treated mucles in mdx mice.
1. Wnt7a signaling through its receptor Fzd7 accelerates and augments regeneration by:
1. stimulating satellite stem cell expansion through the planar cell polarity pathway, as well as,
2. myofiber hypertrophy through the AKT/mammalian target of rapamycin (mTOR) anabolic pathway. 

Application:

1. Duchenne muscular dystrophy (DMD)

References: 

1. J. von Maltzahn, J.-M. Renaud, G. Parise, M. A. Rudnicki.Wnt7a treatment ameliorates muscular dystrophy.Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1215765109